Bactroban Ointment Special Precautions

In the rare event of a possible sensitisation reaction or severe local irritation occurring with the use of Mupirocin (Bactroban) 2% Cream/Ointment, treatment should be discontinued, the product should be washed/wiped off and appropriate alternative therapy for the infection instituted.
As with other antibacterial products, prolonged use may result in overgrowth of non-susceptible organisms.
Pseudomembranous colitis has been reported with the use of antibiotics and may range in severity from mild to life-threatening. Therefore, it is important to consider its diagnosis in patients who develop diarrhoea during or after antibiotic use. Although this is less likely to occur with topically applied mupirocin, if prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further.
Avoid contact with the eyes. If contaminated, the eyes should be thoroughly irrigated with water until the ointment residues have been removed.
Renal impairment: Polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys. In common with other polyethylene glycol based ointments, mupirocin (Bactroban) 2% ointment should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment. This mupirocin ointment formulation is not suitable for: ophthalmic use, intranasal use, use in conjunction with cannulae and at the site of central venous cannulation.
Ability to perform tasks that require judgement, motor or cognitive skills: No adverse effects on the ability to drive or operate machinery have been identified.